Cracking Cancer with CRK
نویسندگان
چکیده
In our true scholarly spirit, the MJM remains committed to supporting budding scientist at all stages of their careers. This year we are pleased to provide you with a unique collection of abstracts outlining the high caliber projects that were undertaken by the most recent winners of the 27th annual Montreal Regional Science and Technology Fair (MRSTF) that was held at Marianopolis College from March 22-24th 2009. This unique event not only invites hundreds of students from greater Montreal area high schools and CEGEPs to present their projects to their peers, but also permits them with a unique opportunity to interact with leading researchers and university professors from top academic institutions. By supporting such initiatives the MJM hopes to further encourage young scientists and engineers to pursue their interests in the sciences so that they may excel and can become tomorrow’s leaders.
منابع مشابه
Prognostic value of microRNA-126 and CRK expression in gastric cancer
BACKGROUND MicroRNA (miR)-126, acting as a tumor suppressor, has been reported to inhibit the invasion of gastric cancer cells in part by targeting v-crk sarcoma virus CT10 oncogene homologue (CRK). The aim of this study was to investigate the clinical significance of miR-126/CRK axis in gastric cancer. METHODS miR-126 and CRK mRNA expression levels were detected by real-time quantitative rev...
متن کاملAdaptor protein CRK induces epithelial–mesenchymal transition and metastasis of bladder cancer cells through HGF/c-Met feedback loop
We have previously reported that an adaptor protein CRK, including CRK-I and CRK-II, plays essential roles in the malignant potential of various aggressive human cancers, suggesting the validity of targeting CRK in molecular targeted therapy of a wide range of cancers. Nevertheless, the role of CRK in human bladder cancer with marked invasion, characterized by distant metastasis and poor progno...
متن کاملCrk II silencing down-regulates IGF-IR and inhibits migration and invasion of prostate cancer cells
Crk (C10 regulator of kinase) adaptor proteins are highly expressed in many types of human cancers and often contribute to aggressive cancer phenotypes. Crk II, a member of CRK family, has been reported to regulate cell migration and metastasis in breast cancer cells. However, its role in other cancer types has not been reported. In this study, we investigated the molecular function of Crk II i...
متن کاملCrkI and CrkII function as key signaling integrators for migration and invasion of cancer cells.
Crk adaptor proteins play an important role during cellular signaling by mediating the formation of protein complexes. Increased levels of Crk proteins are observed in several human cancers and overexpression of Crk in epithelial cell cultures promotes enhanced cell dispersal and invasion, implicating Crk as a regulator of invasive responses. To determine the requirement of Crk for invasive sig...
متن کاملNovel signaling collaboration between TGF-β and adaptor protein Crk facilitates EMT in human lung cancer
The signaling adaptor protein Crk has been shown to play an important role in various human cancers. However, its regulatory machinery is not clear. Here, we demonstrated that Crk induced EMT in A549 human lung adenocarcinoma cells through differential regulation of Rac1/Snail and RhoA/Slug, leading to decreased expression of E-cadherin and increased N-cadherin, fibronectin, and MMP2 expression...
متن کاملGenetic Susceptibility on CagA-Interacting Molecules and Gene-Environment Interaction with Phytoestrogens: A Putative Risk Factor for Gastric Cancer
OBJECTIVES To evaluate whether genes that encode CagA-interacting molecules (SRC, PTPN11, CRK, CRKL, CSK, c-MET and GRB2) are associated with gastric cancer risk and whether an interaction between these genes and phytoestrogens modify gastric cancer risk. METHODS In the discovery phase, 137 candidate SNPs in seven genes were analyzed in 76 incident gastric cancer cases and 322 matched control...
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